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[5] [10] By activating the GLP-1 receptor, retatrutide is thought to stimulate insulin secretion in a glucose-dependent manner, suppress glucagon release, and reduce appetite

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Inhibition of TRPC4 channel activity in colonic myocytes by tricyclic antidepressants disrupts colonic motility causing constipation

None of that is complicated for a trained professional, and that is the point worth stressing