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Combined treatment with ovastatin and lovastatin (a cholesterol-lowering agent) inhibited epidermal growth factor-induced migration of anaplastic TC cells ( in vitro and in vivo mouse model of anaplastic TC showed that troglitazone + Lovastatin display anti-cancer effects such as reduction of cell proliferation and tumor regression (Zhong et al., 2018)

598 In an open-label trial in 143 adults with metabolic syndrome, treatment with a standardized aronia extract for 28 days led to improvements in body weight, cholesterol levels, blood pressure, and blood glucose levels

However, these should be avoided if fever, bloody stools, or severe abdominal pain are present

Its approval means it has undergone Phase 3 clinical trials, FDA safety review, and ongoing post-market surveillance