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This experiment suggests that long-term pre-iron supplementation may reduce fertility or be associated with iron overload and iron death

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In: Bonet S, Casas I, Holt WV, Yeste M (eds) Boar reproduction, 1st edn

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Notably, RSL3 is widely used as a pharmacological inhibitor of GPX4, although studies in cell-free systems suggest that it may also exhibit inhibitory activity toward thioredoxin reductase 1 (TXNRD1), a key NADPH-dependent antioxidant enzyme that maintains thioredoxin-mediated redox homeostasis