PubMed Bock-Marquette, I., Saxena, A., White, M.D., Dimaio, J.M., & Srivastava, D
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"Conformational changes on substrate binding to methylmalonyl CoA mutase and new insights into the free radical mechanism"
For people with absorption issues (and most adults over 50 have at least some), oral B12 simply doesnt deliver enough cobalamin to make a felt difference
Oral Supplements Injections act faster and are more reliable in people with absorption issues, while oral supplements can be effective in mild deficiency