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Louis Pain Center
Hupe-Sodmann, K
( E ) IFN- ( Ifng ) expression in freshly isolated NH cells from Glp1r Tie2+/+ ( n = 7) and Glp1r Tie2/ ( n = 6) mice were cultured overnight with CD3/CD28 stimulation with or without exendin-4 (Ex-4
Although the liver enzyme elevations across the broader danuglipron database were described as in-line with approved GLP-1 agents, the single serious case, combined with regulatory input, led Pfizer to terminate the program entirely
In this Review, we discuss common reasons for GLP1R agonist and tirzepatide discontinuation and examine available evidence related to potential cardiometabolic consequences
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