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accordingly, glutamine synthetase (GS), which promotes glutamine synthesis from glutamate, restrains both M1 macrophage differentiation and antitumor immunity, and its inhibition promotes implanted lung tumors elimination in mice [50, 182]
Researchers studying metabolic syndrome, NAFLD, and obesity have noted these downstream effects as particularly significant for the differentiation between the two compounds
Yeung, Alexander C
Nonogaki, K., Nozue, K
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