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The FDA strengthened Cymbaltas label to include more details about withdrawal symptoms

(PubMed) Teather LA, Wurtman RJ

In one report, patients who lost more than five pounds after starting semaglutide showed reductions in TSH, suggesting that thyroid labs may shift during the early weight-loss phase

Interestingly, nonfatal heart attack showed the largest risk reduction among the three primary outcome components, contrasting with the earlier PIONEER 6 trial where cardiovascular death was the dominant benefitlikely because SOUL's longer follow-up and larger sample size (approximately three times that of PIONEER 6) allowed more comprehensive assessment of cardiovascular outcomes