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Scientific interest has focused on how combined receptor activity may affect appetite signaling, energy balance, glucose regulation, insulin-related pathways, and lipid metabolism

As tirzepatide is a relatively new medication whose side effect profile has yet to be fully characterized, clinicians should be aware of this rare yet potentially fatal complication. Although GLP-1 receptor agonists show impressive efficacy and favorable side effect profiles, it is necessary that we determine all risks and side effects, particularly rare ones, to minimize chances of poor outcomes, says the papers first author Eli J

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