semaglutide vs orlistat Alternatives for Weight Loss in Germany: What Are Your Options? What's New in Obesity Treatment?

10.1007/s12016-021-08899-6 Clin Rev Allergy Immunol

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TGF-1, transforming growth factor beta 1

In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

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