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Whilst these in vitro results could potentially represent an artefact of the co-cultures employed, we showed that functional ATP-dependent cross-talk with afferent nerves is also observed in an acute ex vivo colonic preparation

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4 Clinical testing and assessment related to ferroptosis 4.1 Biomarkers 4.1.1 Definition and mechanism of ferroptosis biomarkers Ferroptosis, as a novel form of programmed cell death, involves complex mechanisms and multiple biomolecules and metabolic pathways (54, 55)

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Successively, it was shown that TIGAR, a protein involved in the inhibition of the glycolytic pathway, could limit starvation-induced ATG by means of its ability to indirectly suppress ROS production (Deffieu et al., 2009)

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2016;354:i4515

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