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However, the addition of glycerol, sucrose and other polyhydric alcohols increases the stability of the protein by helping in protein folding [29]
According to FDA prescribing information, injection site reactions occur in a measurable proportion of patients receiving semaglutide
While these drugs may prove largely safe in the short and long term, the attitude toward them as a quick weight-loss aid does seem to echo what drove the Fen-Phen craze in the 90s an all-too-quick willingness to take a drug that some say promises fast and easy weight loss without a critical look at the reality of that statement or the potential side effects
The included trials were those with administration of recombinant semaglutide in which PK samples, assessed via liquid chromatography and tandem mass spectrometry (LCMS/MS) [3], were available at the time of the analysis
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