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Dose adjustments in older adults typically involve starting at the lower end of the range (100 to 150 mcg per injection) and titrating based on IGF-1 response and tolerability, given that baseline GH reserve is lower and water-retention side effects may be more symptomatic in older patients with pre-existing cardiovascular conditions
Focusing on SIRT3, recent studies indicate that its activation is generally protective
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FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 35 (5), e21526
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