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Considering that the water molecules were trapped largely in the hydrophobic pockets, often made contacts with or were displaced by the fragments, and did not appear to play a structural role, we anticipated that their displacement with larger non-polar moieties would improve binding of newly designed inhibitors

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Ahmann A, Rodbard HW, Rosenstock J, Lahtela JT, de Loredo L, Torne K, Boopalan A, Nauck MA

While type 2 diabetes account for a relatively higher market share, it is worth highlighting that the non-alcoholic steatohepatitis segment is expected to witness substantial market growth in the coming years

doi: 10.1523/JNEUROSCI.0529-11.2011 66 HamiltonAHlscherC