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The most common GI side effects reported were [15]: Nausea (44.2%) Diarrhea (31.5%) Vomiting (24.8%) Constipation (23.4%) Dyspepsia (10.3%) Abdominal pain (10.0%) The trial also reported potentially serious side effects that may occur due to the inhibitory effect of GLP-1 on cholecystokinin synthesis and gallbladder motility, which delays gallbladder emptying [56]

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That low bioavailability alters anticipated dosing, risk, and benefit

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