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The developed strategy showed that the dendriplex PURE G4 -LA 12 -anti- GLS1 -siRNA was effective in crossing the in vitro BBB, as observed by NMR analysis (Figs
This foundational discovery later recognized with the 2024 LaskerDeBakey Clinical Medical Research Award for Habener, Mojsov, and Lotte Bjerre Knudsen laid the foundation for an entirely new class of GLP-1 medications.[1] Gut releases natural GLP-1 that is destroyed in the bloodstream within about two minutes by the enzyme DPP-4 that is a widely distributed integral membrane protein that is expressed in the intestine, kidney, vascular endothelium, liver pancreas, glandular epithelial cells, and immune system cells.[17] Hence, DPP-4 inhibitors are a successful class of anti-hyperglycaemic agents used to treat type 2 diabetes (T2DM) via protecting GLP-1
These medications are used to treat conditions like obesity, diabetes, and heart disease, and the initiative is part of a broader effort to improve drug affordability and access through the TrumpRx public-private partnership
76 WHO (2015)
