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Its relevance comes from its combined GLP-1, GIP, and glucagon receptor activity profile, making it useful for laboratory models examining how multiple incretin and metabolic signaling pathways interact within the same experimental framework
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This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38