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Since obesity is a long-term condition, some people may need ongoing treatment

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(2025), in Diabetes, Obesity and Metabolism, reported a weighted mean difference of 1.02 kg in lean body mass across 19 RCTs

Elderly patients should be given low doses of amitriptyline hydrochloride in the beginning , and closely monitored for any side effects as they can be more common than in younger patients

The compound functions as a dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor, two signaling systems that play central roles in endocrine regulation of metabolism