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In its trials, orforglipron produced average weight loss in the range of roughly 11% to 12% less than the top injectables, but a clinically meaningful result, and in a head-to-head trial it outperformed oral semaglutide on both weight and blood-sugar reduction
Side Effects and Tolerability: What to Expect Gastrointestinal side effects are common to both medications but may occur at different frequencies
GLP-1 receptor agonist market size was USD 52.92 billion in 2025
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