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Research Gaps Based on the mapped evidence from the 18 included interventional studies (15-32), several notable research gaps were identified, underscoring the need for more rigorous and standardized investigations in the field of pharmacological and nutraceutical interventions for chronic hemodialysis complications

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

Too concentrated, and each injection delivers more than intended

Semaglutide or Tirzepatide: GLP-1 receptor agonists work through entirely different mechanisms (appetite suppression, glucose regulation, delayed gastric emptying) compared to AOD-9604s direct lipolytic effects

Vitamin B12 injections are suitable for most individuals, particularly those experiencing fatigue, low energy, or difficulty absorbing B12 through diet