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"While bioavailability may be lower with oral dissolving tablets compared to injectable formats, this can actually be advantageous for specific patient needs," said Kumar

"Es probable que la introduccin de un GLP-1 oral aumente an ms la demanda, por lo que es an ms importante que las personas comprendan todos los factores involucrados, incluidos los costos, los efectos secundarios y si estos medicamentos son adecuados para sus objetivos de salud a largo plazo", dijo Petruzzelli

Peer review Peer review information Nature Reviews Cardiology thanks Luigi Fontana and the other, anonymous, reviewers for their contribution to the peer review of this work

Individuals who may warrant closer monitoring include: Those with a personal or family history of depression , anxiety, or other mood disorders People who have previously experienced mood changes on other weight-loss medications or GLP-1-based therapies Individuals with eating disorders or a complex relationship with food , for whom appetite suppression may have psychological implications (see NICE guideline NG69: Eating disorders: recognition and treatment) [10] Those experiencing significant life stressors alongside starting a new treatment People with poorly controlled type 2 diabetes , where fluctuating blood glucose levels both hypoglycaemia and hyperglycaemia can independently affect mood, concentration, and emotional wellbeing It is also worth acknowledging that obesity itself is associated with higher rates of depression and anxiety, and that the psychological experience of rapid body weight change whether positive or negative can be emotionally complex