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The NHS advises that taking up to 2 mg (2000 micrograms) daily in supplements is unlikely to cause harm
CONCERN #15: GENERAL WELLNESS AND LONGEVITY Description: You're not necessarily "sick," but you're not thriving
Such a study requires a drug which is practically specific for one condition whose prevalence is known, and the one which approximates most closely to this appears to be vitamin B12
Even brief periods outside refrigeration reduce stability
Case reports and small open-label use in clinics pop up online, but without standardized outcome measures, no control groups, and no objective biomarkers
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