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Effect of liraglutide on thigh muscle fat and muscle composition in adults with overweight or obesity: Results from a randomized clinical trial

No obvious effect on thyroxine exposure was seen with SNAC alone, indicating that the increased exposure may be due to the delayed gastric emptying effect of semaglutide [74]

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If fatigue persists beyond 8 to 12 weeks at a stable dose, consult your healthcare provider to investigate other potential causes like nutritional deficiencies or thyroid dysfunction