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The trial population is 55-85 year old patients with mild cognitive impairment (MCI) or mild dementia due to AD with confirmed amyloid abnormalities on PET or CSF analysis

Active ingredient Liraglutide Semaglutide Brand names and uses Victoza : Type 2 diabetes (off-label for weight loss) and to prevent heart disease Saxenda : Weight loss and to prevent heart disease Generic liraglutide: Type 2 diabetes (off-label for weight loss) Ozempic : Type 2 diabetes (off-label for weight loss) Wegovy : Weight loss and preventing heart disease Rybelsus : Type 2 diabetes (off-label for weight loss) Manufacturer Victoza and Saxenda: Novo Nordisk Generic liraglutide: Teva Pharmaceuticals, Hikma Pharmaceuticals Novo Nordisk How its taken Daily injection Ozempic and Wegovy : Weekly injection Rybelsus : Daily pill Effectiveness 9% average body weight loss after 12 months (3.0 mg dose) 15% average body weight loss after 12 months (2.4 mg dose/Wegovy) 4% average body weight loss in 12 months with Rybelsus (14 mg dose) Cost monthly Victoza : $544 (2-pen), $815 (3-pen) Saxenda : $1,349 Generic liraglutide: $470 (2-pen), $700 (3-pen) *Price per month will depend on the dose

However, there are conflicting results, making it difficult to recommend Glutamine for these purposes