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Reward Pathways: GLP-1 RAs modulate the mesolimbic reward system (including the ventral tegmental area and nucleus accumbens), potentially reducing the hedonic drive to consume palatable foods and even moderating addictive behaviors (Zheng et al., 2024)

Retatrutide (LY3437943) is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R)

Lin K, Zheng W, Guo M, Zhou R, Zhang M, Liu T

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