In these instances, we work on lifestyle modification and collaborate with our endobariatric colleagues to provide the latest minimally invasive techniques for managing weight regain, while also using medications like GLP-1 receptor agonists to help people achieve the healthiest weight possible
For the second primary endpoint of percentage change in body weight from baseline to 52 weeks, semaglutide had a consistent beneficial effect across diuretic use categories
Side Effects: Similar to canagliflozin References: Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)
Sheikh, M
In 2023, Juan P Frias and colleagues, in The Lancet, published the first phase two clinical trial of orforglipron, which investigated the use of a small-molecule oral GLP-1R agonist called orforglipron in type 2 diabetes, which can be taken at any time of the day without restrictions on food and water intake (Frias et al., 2023)