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When they reach a critically short length, the cell can no longer divide a state called replicative senescence, also known as the Hayflick limit

Amide bond Ester bond is relatively weaker than amide bond, it will be rapidly hydrolyzed by esterase enzyme Example Procaine Short acting local anesthetic Procainamide Long acting antiarrhythmic T1/2 = 40-84 second T1/2 = 2.5-4.5 hr Hydrolytic phase-I metabolism Examples of prodrugs activated by hydrolytic enzymes: Dipivefrine: is a di-tertbutylcarboxy ester of adrenaline

Wu GS, Guo JJ, Bao JL, Li XW, Chen XP, Lu JJ, Wang YT (2013) Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum a review

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3.1.2 Lipid profile IF has notable impacts on lipid profiles by influencing cholesterol, triglycerides, and other important markers in 4 major ways: 1- Decreasing total cholesterol and low-density lipoprotein (LDL) cholesterol: Research indicates that IF reduces total cholesterol and LDL cholesterol levels