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The receptor is there, the peptide binds, but the downstream cascade doesn't trigger
Nature Medicine
The Thiazolidinediones Or Sulfonylureas and Cardiovascular Accidents Intervention Trial (TOSCA.IT) is the only major trial to have assessed the CVOT from using older diabetes drugs as second-line agents to metformin in T2D individuals with mild-to-moderate cardiovascular risk [50]
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