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First, semaglutide activates GLP-1 receptors in the brain, particularly in the hypothalamus, which reduces appetite and changes how you experience hunger

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It is essential to promote a healthy gut microbiome by consuming a balanced diet with fiber-rich foods, avoiding processed foods, and taking probiotics or fermented foods

If you choose to drink while on tirzepatide, following these guidelines reduces risk: limit consumption to one standard drink (12 oz beer, 5 oz wine, or 1.5 oz spirits), avoid drinking on an empty stomach, stay well-hydrated by drinking water alongside alcoholic beverages, and never exceed recommended limits