Despite extensive animal data suggesting efficacy across depression, anxiety, cognitive decline, and ADHD-relevant models, not a single human clinical trial exists for any mental health application
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But the specific protocols differ in meaningful ways
That is part of how they work
Composition varies slightly between compounding facilities, but therapeutic formulations typically contain methionine (2550 mg), inositol (50100 mg), choline (50100 mg), and B-complex vitamins (B1, B5, B6, B12) at doses ranging from 15 mg per compound