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In keratoconus, CD56 natural killer cells were observed to be regulated by AKR1C3, the depletion of which might result in a reduction of SLC7A11 expression and subsequent interruption of the system Xc- (68)

These antibodyantigen complexes can precipitate and get stuck in certain locations, such as blood vessels in the skin, kidneys and joints, where they activate the complement cascade to cause local damage

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