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This is particularly important for drugs with a narrow therapeutic index or those that require specific blood concentrations to be effective

In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]

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Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia

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