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However, subsequently, in a trial that I led of nearly 19,000 participants in 42 countries around the world, there was a significant excess of depression, neuropsychiatric side-effects and suicidal ideation which spelled the end of that drugs life

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Together, we will work with you to develop a plan for sustainable healthy weight loss

Prevention strategies include maintaining adequate protein intake (minimum 80-100g daily), taking biotin supplements (2,500-5,000mcg daily), avoiding crash dieting on top of medication effects, and ensuring sufficient iron and zinc intake

Beyond those exclusions, it lists gastrointestinal side effects, dehydration risk, and thyroid concerns in specific populations as considerations