17 In addition to these findings, the SUSTAIN-6 trial also showed that semaglutide can offer a significant reduction in the risk of new or worsening nephropathy including persistent macroalbuminuria, increase in serum creatinine or the need of renal replacement therapy
This is due to a variety of issues, from procurement, supply chain, and financial coverage, to the accessibility, affordability and availability of GLP-1 receptor agonists [which] remain highly inadequate to meet the population-level needs. Mind the evidence gap Despite the plethora of short-term evidence for GLP-1s in the management of weight loss, almost nothing is known about the possible long-term effects of these artificial peptide hormones
Lancet 2015;385:2067-2076
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