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Avoid excessive heat
LPS at 25 g/kg caused more than 75% fetal loss in rats
Interestingly, it activates defense mechanisms against oxidative stress at low concentrations, such as Nrf2 and heat shock factor 1 (Sharma et al., 2008a
The study did not apply a modern multi-dose response-surface, Bliss independence, or Loewe additivity analysis, so the term synergistic should be understood as reflecting the original authors terminology under their specific experimental design
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