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Notably, treatment cohorts in RCTs typically report more pronounced effects than controls for the primary outcomes we assessed, and in our real-world study, there was a clear continuum of responsiveness to GLP-1s, suggesting a high degree of variation in terms of patient benefit from GLP-1s

They do not reliably predict what will happen in a human knee that has to bear weight, twist, and absorb load through repaired tissue

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Research into combining agonism of the GLP-1 receptor with GIP, glucagon and possibly other receptors is ongoing, as well as novel mechanisms of drug delivery, for example, by inhalation

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