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Nature 457 , 599 (2008)
One potential pathway involves activation of phospholipase C, which may then generate two second messengers: IP and diacylglycerol (DAG)
For example, in recurrent colorectal cancer, metastatic outgrowth is driven by Lgr5 + stem cells directly or by Lgr5 + cells that have transformed from Lgr5 non-stem cells via phenotypic conversion 10,11
Both contain semaglutide, but Wegovy is approved specifically for weight loss, while Ozempic is mainly used to treat type 2 diabetes
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