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Hyperglycemic conditions and the resultant metabolic disorder primarily disrupt autophagy by blocking autophagic flux and compromising lysosomal function, ultimately leading to stagnation of the autophagy pathway (146, 147)

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doi: 10.1038/nri3862 90 AlfeiFKanevKHofmannMWuMGhoneimHERoelliPet al

Postruminal lysine and methionine infussion in steers fed a urea-supplemented diet adequate in sulfur

Scientific study has also addressed its stability properties across biological matrices, pharmacokinetic behavior in preclinical species, and interaction with the dopaminergic system in controlled neurological research models