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GLP1 and cardiovascular outcomes in patients with type 2 diabetes

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The Biological Mechanism Behind GLP-1 Receptor Activation At the molecular level, GLP-1 receptor agonists function by binding to and activating G-protein coupled receptors (GPCRs) known as GLP-1 receptors

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Notably, a relative increase in the NMDAR GluN2B subunit confers slower receptor decay times enabling a greater volume of Ca 2+ influx through the receptor, thereby increasing the risk of Ca 2+ -mediated excitotoxicity and neuronal death

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