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In fact, platelet-activating factor binding to PAFr leads to the production of inositol trisphosphate (IP3) through the phosphatidylinositol cycle, which in turn binds to inositol 1,4,5-triphosphate receptor type 1 (IP3R1) to induce the release of Ca 2+ stored in the endoplasmic reticulum (Kroegel et al., 1989
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2021 Aug;10(4):541-544
Understanding the interplay between heparanase and calcium ions is crucial, as it may provide insights into potential therapeutic targets for conditions characterized by endothelial dysfunction, such as atherosclerosis and diabetic vascular complications
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