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Recent studies have shown that the mammalian gut microbiota is involved in the regulation of bile acid synthesis and metabolism (Jones et al., 2008), and that BAs can be further modified by specific enzymes in the gut microbiota, such as bile salt hydrolase (BSH) and bile acid dehydratase
One of these classes (class I ferroptosis-inducing compounds, erastin derivatives) inhibits GPX4 through the depletion of glutathione, and the other (class II ferroptosis-inducing compounds, RSL3 derivatives) inhibits GPX4 directly, without glutathione depletion
2013;93(4):1803-45 [8] Corona C, Frazzini V, Silvestri E, et al
These signs often blend into daily life, so they are easy to overlook, but catching them early can really help
Data were normalized to Tbp and analyzed using the Ct method as previously described 136
