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Importantly, Canx (-/-) cells have significantly increased proteasomal activity, which may play a role in the adaptive mechanisms addressing the acute ER stress observed in the absence of Canx [70]

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It is important to mention that these O 2 levels do not represent the concentrations found inside human healthy and cancerous tissues and are followingly used to investigate the different therapeutic efficiency of the nanoparticle formulation in high and low O 2 atmospheres