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Polyphenol bioavailability is less than 10%, whereas sulforaphane bioavailability is 82%.[5] A study on mice found that sulforaphane upregulated and activated Nrf2 and prevented angiotensin II-induced cardiomyopathy (Angiotensin II is involved in diabetic cardiomyopathy).[6] Altering Gene Expression Epigenetics is the study of gene expression, the ability to turn our genes on or off