In a small randomized crossover trial, daily 15mg of pioglitazone in CAPD patients (both with and without DM) showed improved insulin resistance, adipokine balance, with reduced markers of inflammation.40 In the diabetic PD population, pioglitazone may be continued without any dose adjustments on PD-free days without increases risk of hypoglycemia.24 The main drawback to its use is related to its adverse effect profile on fluid retention, meaning that it is usually an alternative to other agents with a better safety profile
Ion-pair chromatography offers an effective solution to this challenge
An addition to the Optum Rx Concurrent Drug Utilization Review (cDUR) program, the new solution uses Duplicate Therapy (DUPTHER) screening to ensure members are using appropriate doses of GLP-1 medications
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And even when physicians are prescribing GLP-1RAs for their intended uses, its not a magic formula there are complex considerations such as dosages, costs, side effects and comparisons between specific drugs
