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In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected

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For Canadian researchers, the practical takeaways: AOD-9604 isolates lipolytic activity without engaging GH receptors or affecting IGF-1 Tesamorelin activates the full GH axis through pituitary release of endogenous GH Both have substantive published research bases with different shapes Choice depends on whether isolated vs full-axis GH biology effects are the research goal Same quality framework Janoshik third-party testing applies to both For continued reading, see What Is AOD-9604

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