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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

van den Bos MAJ, Geevasinga N, Higashihara M, Menon P, Vucic S

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Thymosin beta-4derived peptides such as TB-500 are widely investigated in wound-healing research because actin-mediated cellular migration is essential for epithelial repair, fibroblast movement, and structural reorganization of damaged tissue

However, its important to know what minor issues could pop up and how to use peptides safely