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Keywords: tumor resistance, glutathione S -transferase pi, drug treatment Introduction In addition to combating a variety of noxious substances from the external environment, cell-detoxification mechanisms are capable of resisting the deleterious effects of certain endogenous substances (eg, ROS, a product generated from normal cellular metabolism), in order to maintain physiological homeostasis

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When necessary, fatty acids are metabolized through beta-oxidation (or fatty acid oxidation) in the mitochondria, and energy is produced in the form of adenosine triphosphate

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