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NPs-induced downregulation of endothelial nitric oxide synthase (eNOS) expression, causing impaired endothelium-dependent vasorelaxation and promoting reactive oxygen species creation in endothelial cells, which was associated with high NADPH oxidase expression, with subsequent downregulation of Sirt1 expression [76]
The prognosis of these neurological syndromes was not related to blood ammonia levels
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
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