"This research is very important because alcohol and drug addiction are major causes of illness and death, yet there are still only a few effective treatment options," said lead researcher Lorenzo Leggio, MD, Ph.D., of the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism
Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes
Current human evidence does not show that GLP-1 medications cause thyroid nodules or the common types of thyroid cancer (like Papillary cancer)
It may have neuroprotective effects because of the reduction of oxidative stress in the brain
This translated to a 1.6 point drop in BMI, compared to 1.1 for the placebo