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The cationic amino acid transporter-2 (CAT-2) mediates arginine uptake, which is required for arginase activity and subsequent collagen production, particularly in macrophages [74]

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Li, J., Wang, D

DADS and DATS inhibited the expression of adhesion molecules, E-selectin and vascular cell adhesion molecule-1 (VCAM-1), on endothelial cell surface by reversing oxidized LDL-induced inhibition of PI3K/Akt and cAMP responsive element binding protein (CREB) signaling pathways (50)

In collagen lab studies, higher concentrations drove more collagen synthesis, so serums built around centella tend to feature it more prominently