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Safety and Long-Term Use GLP-1 medications have been used for diabetes for over a decade, with extensive safety data

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Sedation and tiredness were commonly reported with drugs targeting the opioid receptors (like naltrexone) and combination therapies that target both the opioid and monoamine systems (such as Contrave)

Eli Lilly is likely considering MASLD as a separate indication for regulatory submission, which could accelerate the timeline for liver-specific approval

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